Trazodone (Desyrel Generic) – Complete Product Information

What is Trazodone?

Trazodone is a prescription medication used primarily to treat major depressive disorder. It belongs to a class of drugs called serotonin antagonist and reuptake inhibitors (SARIs). It is also commonly prescribed off-label for insomnia because of its sedating effects. The brand name is Desyrel (immediate-release) and Oleptro (extended-release).

Trazodone works by increasing the activity of serotonin in the brain, which helps improve mood and promote sleep. It has been used safely for decades and is a common alternative for patients who do not tolerate other antidepressants well.

What is Trazodone Used For?

According to the FDA, trazodone is approved to treat:

• ✔️ Major depressive disorder – helps relieve symptoms of depression.

In clinical practice, doctors also commonly prescribe trazodone off-label for:

• ✔️ Insomnia – especially when associated with depression or anxiety.
• ✔️ Anxiety disorders – may help reduce anxiety symptoms.

Always follow your prescriber's instructions regarding the use of trazodone.

Available Dosages and Forms

Trazodone is available as oral tablets in several strengths:

• Tablets: 50 mg, 100 mg, 150 mg, 300 mg
• Extended-release tablets (Oleptro): 150 mg, 300 mg

Generic trazodone is available in the same strengths and is equally effective, usually at a lower cost.

Brand Desyrel / Oleptro vs Generic Trazodone

Both contain the same active ingredient and meet the same FDA standards for quality, safety, and effectiveness. The only significant difference is price: generic trazodone is typically much less expensive. Most insurance plans prefer or require generics.

When comparing prices, you may see both options. Choose the one that best fits your budget and prescription.

How to Take Trazodone Safely

Always follow your healthcare provider's instructions. Trazodone is usually taken once daily, often in the evening because of its sedating effects. It can be taken with or without food.

1. Take trazodone at the same time each day, preferably in the evening.
2. If you miss a dose, take it as soon as you remember unless it is close to your next dose.
3. Do not take a double dose to make up for a missed one.
4. Do not stop taking trazodone suddenly without consulting your doctor, as withdrawal symptoms may occur.
5. It may take several weeks to feel the full antidepressant benefits.

Common Side Effects and Precautions

Like all medications, trazodone may cause side effects. The most common include:

• Drowsiness or fatigue
• Dizziness or lightheadedness
• Dry mouth
• Nausea
• Headache
• Blurred vision

Serious side effects requiring immediate medical attention include priapism (prolonged erection), fainting, irregular heartbeat, and suicidal thoughts. This is not a complete list. Read the full FDA label or consult your pharmacist.

Important: Trazodone may interact with MAO inhibitors, other antidepressants, blood thinners, and alcohol. Tell your doctor about all medications and supplements you take.

📚 Medical Sources We Rely On

All product information is based on official FDA labeling (FDA Trazodone Approval) and peer-reviewed research available on PubMed. Our content is reviewed by a licensed pharmacist. See our About page for credentials.